An interesting read! Spaz, has your head-canon Foundation attempted reproduction of the same exact setup of this room in a controlled setting, to try to understand what causes the cognitohazard? Perhaps its effects could be studied or investigated somehow.
Oh, upon mention of the 60s song, the first thing I thought was "Yellow Submarine" - and lol'd, heartily, at the mental image.
I've done the whole 3D level editor thing in the past, and I can vouch for the unnerving sensation… it gets even worse if you load it up and start moving around in it, too.